ADP-specific glucokinase

In enzymology, an ADP-specific glucokinase (EC 2.7.1.147) also known as ADP-dependent glucokinase is an enzyme that catalyzes the chemical reaction

ADP + D-glucose ${\displaystyle \rightleftharpoons }$ AMP + D-glucose 6-phosphate

ADP-specific glucokinase
Identifiers
EC no.	2.7.1.147
CAS no.	173585-07-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

ADPGK
Identifiers
Aliases	ADPGK, 2610017G09Rik, ADP-GK, ADP-specific glucokinase, ADP-dependent glucokinase, ADP dependent glucokinase
External IDs	OMIM: 611861; MGI: 1919391; HomoloGene: 41739; GeneCards: ADPGK; OMA:ADPGK - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.1 Start 72,751,294 bp[1] End 72,785,846 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 59,198,841 bp[2] End 59,231,335 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte monocyte secondary oocyte granulocyte spleen bone marrow cell blood upper lobe of left lung appendix body of pancreas Top expressed in secondary oocyte bone marrow yolk sac cumulus cell somite proximal tubule lip blood spermatocyte molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphotransferase activity, alcohol group as acceptor transferase activity metal ion binding kinase activity ADP-specific glucokinase activity Cellular component endoplasmic reticulum membrane extracellular region endoplasmic reticulum membrane Biological process glycolytic process phosphorylation glucose metabolic process canonical glycolysis carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83440 72141 Ensembl ENSG00000159322 ENSMUSG00000025236 UniProt Q9BRR6 Q8VDL4 RefSeq (mRNA) NM_031284 NM_001365223 NM_001365224 NM_001365225 NM_001365226 NM_001365227 NM_001365228 NM_001365229 NM_028121 NM_001359282 RefSeq (protein) NP_112574 NP_001352152 NP_001352153 NP_001352154 NP_001352155 NP_001352156 NP_001352157 NP_001352158 NP_082397 NP_001346211 Location (UCSC) Chr 15: 72.75 – 72.79 Mb Chr 9: 59.2 – 59.23 Mb PubMed search [3] [4]
Wikidata
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Thus, the two substrates of this enzyme are ADP and D-glucose, whereas its two products are AMP and D-glucose 6-phosphate.

This enzyme belongs to the family of transferases, to be specific those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor.

In humans, the ADP-dependent glucokinase is encoded by the ADPGK gene.^[5]

Structural studies

Examples of the ADP-dependent glucokinase structure solved by x-ray crystallography include the enzyme from mouse PDB accession code 5CCF and Archaea 1GC5.