AFAP1

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.^[5][6][7][8]

AFAP1
Identifiers
Aliases	AFAP1, AFAP, AFAP-110, AFAP110, actin filament associated protein 1
External IDs	OMIM: 608252; MGI: 1917542; HomoloGene: 11009; GeneCards: AFAP1; OMA:AFAP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.1 Start 7,758,714 bp[1] End 7,939,926 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B3 Start 36,050,663 bp[2] End 36,161,267 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium sural nerve right testis left testis ganglionic eminence muscle layer of sigmoid colon epithelium of colon popliteal artery tibial arteries testicle Top expressed in pineal gland decidua iris umbilical cord aorta superior cervical ganglion otolith organ calvaria utricle atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding SH3 domain binding SH2 domain binding Cellular component cytoplasm cytoskeleton focal adhesion cytosol actin cytoskeleton Biological process regulation of signal transduction regulation of cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60312 70292 Ensembl ENSG00000196526 ENSMUSG00000029094 UniProt Q8N556 Q80YS6 RefSeq (mRNA) NM_001134647 NM_021638 NM_198595 NM_001371090 NM_001371091 NM_027373 RefSeq (protein) NP_001128119 NP_940997 NP_001358019 NP_001358020 NP_081649 NP_001390348 NP_001390349 NP_001390350 Location (UCSC) Chr 4: 7.76 – 7.94 Mb Chr 5: 36.05 – 36.16 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.^[8]