AGPAT5

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon is an enzyme that is encoded by the AGPAT5 gene in humans.^[5]

AGPAT5
Identifiers
Aliases	AGPAT5, 1LPAATE, 1-acylglycerol-3-phosphate O-acyltransferase 5
External IDs	OMIM: 614796; MGI: 1196345; HomoloGene: 10153; GeneCards: AGPAT5; OMA:AGPAT5 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.1 Start 6,708,642 bp[1] End 6,761,503 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.3|8 10.3 cM Start 18,896,293 bp[2] End 18,941,377 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum ventricular zone ganglionic eminence left testis right testis endometrium C1 segment Achilles tendon caudate nucleus islet of Langerhans Top expressed in triceps brachii muscle sternocleidomastoid muscle temporal muscle digastric muscle skin of external ear seminal vesicula endothelial cell of lymphatic vessel pineal gland umbilical cord decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein binding acyltransferase activity 1-acylglycerol-3-phosphate O-acyltransferase activity Cellular component integral component of membrane nuclear envelope membrane endoplasmic reticulum membrane mitochondrial outer membrane mitochondrion endoplasmic reticulum nucleus Biological process phosphatidic acid biosynthetic process CDP-diacylglycerol biosynthetic process lipid metabolism hematopoietic progenitor cell differentiation phospholipid biosynthetic process metabolism acylglycerol metabolic process phospholipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55326 52123 Ensembl ENSG00000155189 ENSG00000284980 ENSMUSG00000031467 UniProt Q9NUQ2 Q9D1E8 RefSeq (mRNA) NM_018361 NM_026792 RefSeq (protein) NP_060831 NP_081068 Location (UCSC) Chr 8: 6.71 – 6.76 Mb Chr 8: 18.9 – 18.94 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis.^[5]