AGPAT9

Glycerol-3-phosphate acyltransferase 3 (GPAT-3) is an enzyme that in humans is encoded by the AGPAT9 gene.^[5][6][7][8] GPAT-3 is also known as:

• 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9),
• lysophosphatidic acid acyltransferase theta (LPAAT-theta), or
• lung cancer metastasis-associated protein 1.

GPAT3
Identifiers
Aliases	GPAT3, AGPAT 10, AGPAT8, LPAAT-theta, MAG1, AGPAT9, HMFN0839, AGPAT10, glycerol-3-phosphate acyltransferase 3
External IDs	OMIM: 610958; MGI: 3603816; HomoloGene: 13099; GeneCards: GPAT3; OMA:GPAT3 - orthologs
EC number	2.3.1.51
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.23 Start 83,535,914 bp[1] End 83,605,875 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E4 Start 100,993,579 bp[2] End 101,046,968 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte jejunal mucosa mucosa of ileum myocardium of left ventricle renal medulla Skeletal muscle tissue of rectus abdominis cardiac muscle tissue of right atrium pancreatic epithelial cell buccal mucosa cell duodenum Top expressed in jejunum mammary gland white adipose tissue morula pineal gland granulocyte ileum subcutaneous adipose tissue duodenum epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity acyltransferase activity glycerol-3-phosphate O-acyltransferase activity 1-acylglycerol-3-phosphate O-acyltransferase activity sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process phosphatidic acid biosynthetic process CDP-diacylglycerol biosynthetic process metabolism regulation of TOR signaling lipid metabolism phospholipid biosynthetic process triglyceride biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84803 231510 Ensembl ENSG00000138678 ENSMUSG00000029314 UniProt Q53EU6 Q8C0N2 RefSeq (mRNA) NM_001256421 NM_001256422 NM_032717 NM_172715 RefSeq (protein) NP_001243350 NP_001243351 NP_116106 NP_766303 Location (UCSC) Chr 4: 83.54 – 83.61 Mb Chr 5: 100.99 – 101.05 Mb PubMed search [3] [4]
Wikidata
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Function

Glycerol-3-phosphate (G3P) acyltransferases (GPAT; EC 2.3.1.15), such as GPAM and GPAT3 (this enzyme), catalyze the initial step of de novo triacylglycerol (TAG) synthesis by converting glycerol-3-phosphate (G3P) to lysophosphatidic acid (LPA).^[6]