AGTRAP

Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.^[5][6]

AGTRAP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZV0, 4YAY
Identifiers
Aliases	AGTRAP, ATRAP, angiotensin II receptor associated protein
External IDs	OMIM: 608729; MGI: 1339977; HomoloGene: 7621; GeneCards: AGTRAP; OMA:AGTRAP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 11,736,084 bp[1] End 11,754,802 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E1|4 78.67 cM Start 148,161,518 bp[2] End 148,172,488 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte right uterine tube pancreatic ductal cell blood gastric mucosa spleen right lung upper lobe of left lung bone marrow Top expressed in blastocyst right kidney granulocyte choroid plexus of fourth ventricle proximal tubule gastrula Ileal epithelium yolk sac human kidney embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding angiotensin type II receptor activity Cellular component integral component of membrane Golgi membrane plasma membrane Golgi apparatus cell cortex endoplasmic reticulum membrane cytoplasmic vesicle membrane intracellular membrane-bounded organelle endoplasmic reticulum membrane cytoplasmic vesicle nucleoplasm cytosol Biological process regulation of blood pressure angiotensin-activated signaling pathway response to hypoxia Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57085 11610 Ensembl ENSG00000177674 ENSMUSG00000029007 UniProt Q6RW13 Q9WVK0 RefSeq (mRNA) NM_001040194 NM_001040195 NM_001040196 NM_001040197 NM_020350 NM_001301281 NM_009642 RefSeq (protein) NP_001035284 NP_001035285 NP_001035286 NP_001035287 NP_065083 NP_001288210 NP_033772 Location (UCSC) Chr 1: 11.74 – 11.75 Mb Chr 4: 148.16 – 148.17 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.^[6]

Interactions

AGTRAP has been shown to interact with GNB2L1.^[5]