AGXT

Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene.^[5][6][7]

AGXT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H0C, 1J04, 2YOB, 3R9A, 4CBR, 4CBS, 4I8A, 4KXK, 4KYO
Identifiers
Aliases	AGXT, AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6, alanine-glyoxylate aminotransferase, alanine--glyoxylate and serine--pyruvate aminotransferase, Ser-PyrAT
External IDs	OMIM: 604285; MGI: 1329033; HomoloGene: 37251; GeneCards: AGXT; OMA:AGXT - orthologs
EC number	2.6.1.44
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 240,868,824 bp[1] End 240,880,502 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 D|1 47.0 cM Start 93,062,962 bp[2] End 93,073,143 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver buccal mucosa cell cartilage tissue human kidney testicle kidney tubule cerebellar vermis gonad renal medulla renal cortex Top expressed in left lobe of liver embryo gallbladder sexually immature organism gastrula duodenum jejunum Ileal epithelium CA3 field submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein homodimerization activity amino acid binding alanine-glyoxylate transaminase activity serine-pyruvate transaminase activity transaminase activity protein self-association catalytic activity protein binding pyridoxal phosphate binding signaling receptor binding identical protein binding Cellular component peroxisome mitochondrial matrix peroxisomal matrix mitochondrion intracellular membrane-bounded organelle cytosol Biological process Notch signaling pathway oxalic acid secretion glyoxylate catabolic process glycine biosynthetic process, by transamination of glyoxylate pyruvate biosynthetic process L-alanine catabolic process response to glucocorticoid response to cAMP L-cysteine catabolic process cellular nitrogen compound metabolic process glyoxylate metabolic process protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 189 11611 Ensembl ENSG00000172482 ENSMUSG00000026272 UniProt P21549 O35423 RefSeq (mRNA) NM_000030 NM_001276710 NM_016702 RefSeq (protein) NP_000021 NP_001263639 NP_057911 Location (UCSC) Chr 2: 240.87 – 240.88 Mb Chr 1: 93.06 – 93.07 Mb PubMed search [3] [4]
Wikidata
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This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targeting, have been associated with type I primary hyperoxaluria.^[7]

See also

• Peroxisomal disorder