AGXT2

The human AGXT2 gene encodes the protein Alanine—glyoxylate aminotransferase 2. ^[5]

AGXT2
Identifiers
Aliases	AGXT2, AGT2, DAIBAT, alanine--glyoxylate aminotransferase 2, BAIBA
External IDs	OMIM: 612471; MGI: 2146052; HomoloGene: 12887; GeneCards: AGXT2; OMA:AGXT2 - orthologs
EC number	2.6.1.40
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.2 Start 34,998,101 bp[1] End 35,048,135 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 A1 Start 10,358,618 bp[2] End 10,410,239 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver renal medulla renal cortex human kidney buccal mucosa cell jejunal mucosa gallbladder duodenum caput epididymis muscle tissue Top expressed in left lobe of liver right kidney human kidney proximal tubule embryo yolk sac islet of Langerhans ureter duodenum primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity (R)-3-amino-2-methylpropionate-pyruvate transaminase activity pyridoxal phosphate binding catalytic activity alanine-glyoxylate transaminase activity identical protein binding transaminase activity Cellular component mitochondrial matrix mitochondrion Biological process glycine biosynthetic process, by transamination of glyoxylate positive regulation of nitric oxide biosynthetic process glyoxylate catabolic process L-alanine catabolic process, by transamination glyoxylate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64902 268782 Ensembl ENSG00000113492 ENSMUSG00000089678 UniProt Q9BYV1 Q3UEG6 RefSeq (mRNA) NM_001306173 NM_031900 NM_001031851 NM_001310735 NM_001310736 RefSeq (protein) NP_001293102 NP_114106 NP_001027021 NP_001297664 NP_001297665 Location (UCSC) Chr 5: 35 – 35.05 Mb Chr 15: 10.36 – 10.41 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor.^[6]