AKAP10

A kinase anchor protein 10, mitochondrial is an enzyme that in humans is encoded by the AKAP10 gene.^[4][5]

AKAP10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IM4, 3TMH
Identifiers
Aliases	AKAP10, AKAP-10, D-AKAP-2, D-AKAP2, PRKA10, A-kinase anchoring protein 10
External IDs	OMIM: 604694; MGI: 1890218; HomoloGene: 32452; GeneCards: AKAP10; OMA:AKAP10 - orthologs
Gene location (Mouse) Chr. Chromosome 11 (mouse)[1] Band 11|11 B2 Start 61,762,133 bp[1] End 61,821,078 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon trabecular bone monocyte nipple blood optic nerve bone marrow cells visceral pleura pancreatic ductal cell Top expressed in spermatid endocardial cushion zygote secondary oocyte renal corpuscle medullary collecting duct Rostral migratory stream seminiferous tubule spermatocyte primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase A binding Cellular component plasma membrane membrane mitochondrion cytoplasm cytosol protein-containing complex Biological process blood coagulation signal transduction protein localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11216 56697 Ensembl n/a ENSMUSG00000047804 UniProt O43572 O88845 RefSeq (mRNA) NM_007202 NM_001330152 NM_019921 RefSeq (protein) NP_001317081 NP_009133 NP_064305 Location (UCSC) n/a Chr 11: 61.76 – 61.82 Mb PubMed search [2] [3]
Wikidata
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Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.^[5]

Interactions

AKAP10 has been shown to interact with PDZK1^[6] and PRKAR1A.^[4][7]