AKAP3

A-kinase anchor protein 3 is an enzyme that in humans is encoded by the AKAP3 gene.^[5][6][7]

AKAP3
Identifiers
Aliases	AKAP3, AKAP 110, AKAP110, CT82, FSP95, HEL159, PRKA3, SOB1, A-kinase anchoring protein 3
External IDs	OMIM: 604689; MGI: 1341149; HomoloGene: 4688; GeneCards: AKAP3; OMA:AKAP3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.32 Start 4,615,508 bp[1] End 4,649,051 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F3 Start 126,830,061 bp[2] End 126,851,271 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm testicle gonad islet of Langerhans right atrium right auricle of heart right uterine tube C1 segment Top expressed in seminiferous tubule spermatid spermatocyte embryo supraoptic nucleus olfactory epithelium tibiofemoral joint trachea pancreas substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase A binding Cellular component cytoplasm sperm principal piece acrosomal vesicle motile cilium sperm fibrous sheath cytoplasmic vesicle nucleus Biological process acrosome reaction protein localization transmembrane receptor protein serine/threonine kinase signaling pathway regulation of protein kinase A signaling single fertilization blastocyst hatching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10566 11642 Ensembl ENSG00000111254 ENSMUSG00000030344 UniProt O75969 O88987 RefSeq (mRNA) NM_001278309 NM_006422 NM_009650 RefSeq (protein) NP_001265238 NP_006413 NP_033780 Location (UCSC) Chr 12: 4.62 – 4.65 Mb Chr 6: 126.83 – 126.85 Mb PubMed search [3] [4]
Wikidata
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Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.^[7]

Interactions

AKAP3 has been shown to interact with:

• AKAP4^[8]
• GNA13,^[9] and
• PRKAR2A.^[6][10]