AKAP5

A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.^[5][6][7]

AKAP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H9R, 3LL8
Identifiers
Aliases	AKAP5, AKAP75, AKAP79, H21, A-kinase anchoring protein 5
External IDs	OMIM: 604688; MGI: 2685104; HomoloGene: 15854; GeneCards: AKAP5; OMA:AKAP5 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.3 Start 64,465,499 bp[1] End 64,474,503 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 76,371,665 bp[2] End 76,380,927 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 entorhinal cortex superior frontal gyrus postcentral gyrus nucleus accumbens primary visual cortex endothelial cell caudate nucleus prefrontal cortex Top expressed in left lung lobe olfactory tubercle nucleus accumbens right lung right lung lobe lateral septal nucleus globus pallidus temporal lobe Region I of hippocampus proper amygdala More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase A binding calmodulin binding protein binding protein kinase A regulatory subunit binding adenylate cyclase binding SH3 domain binding protein phosphatase 2B binding beta-2 adrenergic receptor binding molecular adaptor activity glutamate receptor binding GABA receptor binding scaffold protein binding Cellular component cytosol membrane plasma membrane cytoplasmic side of plasma membrane postsynaptic density dendrite membrane dendritic spine membrane raft excitatory synapse intracellular anatomical structure Biological process protein targeting signal transduction positive regulation of protein kinase A signaling chemical synaptic transmission adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway negative regulation of adenylate cyclase activity regulation of protein kinase A signaling positive regulation of adenylate cyclase activity positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9495 238276 Ensembl ENSG00000179841 ENSMUSG00000021057 UniProt P24588 Q6PG46 D3YVF0 RefSeq (mRNA) NM_004857 NM_001101471 RefSeq (protein) NP_004848 NP_004848.3 NP_001094941 Location (UCSC) Chr 14: 64.47 – 64.47 Mb Chr 12: 76.37 – 76.38 Mb PubMed search [3] [4]
Wikidata
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Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin 2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.^[7]

Interactions

AKAP5 has been shown to interact with:

• Calcineurin^[8] and
• GABRB3.^[9]