ALA-10

ALA-10, also known as 1-acetyl-LAE (1A-LAE), is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).^[1][2][3] It is the 1-acetyl derivative of LAE-32.^[2][3][4][5] 1-Acetylated lysergamides like ALD-52 (1-acetyl-LSD; 1A-LSD) are thought to function as prodrugs via deacetylation to the 1-unsubstituted analogues, which in the case of ALD-52 is LSD.^[6][7][8]

ALA-10

Clinical data
Other names	ALA10; 1-Acetyl-LAE; 1A-LAE; 1-Acetyl-LAE-32; 1A-LAE-32; 1-Acetyllysergic acid ethylamide; 1-Acetyl-N-ethyllysergamide; 1-Acetyl-N-ethyl-6-methyl-9,10-didehydroergoline-8β-carboxamide
Routes of administration	Oral
Drug class	Serotonin receptor modulator; Serotonergic psychedelic; Hallucinogen
ATC code	None
Identifiers
IUPAC name (6aR,9R)-4-acetyl-N-ethyl-7-methyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number	50485-03-5
PubChem CID	3039342
ChemSpider	2302828
Chemical and physical data
Formula	C20H23N3O2
Molar mass	337.423 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCNC(=O)[C@H]1CN([C@@H]2CC3=CN(C4=CC=CC(=C34)C2=C1)C(=O)C)C
InChI InChI=1S/C20H23N3O2/c1-4-21-20(25)14-8-16-15-6-5-7-17-19(15)13(11-23(17)12(2)24)9-18(16)22(3)10-14/h5-8,11,14,18H,4,9-10H2,1-3H3,(H,21,25)/t14-,18-/m1/s1 Key:UKRWCEJTOPSTEC-RDTXWAMCSA-N

Use and effects

ALA-10 is active at a dose of approximately 1.2 mg orally in humans and has around 7 to 10% of the potency of LSD.^{[1][2][3][9][10]} It produces LSD-like psychic effects.^[2][10] It is said to have a quicker onset and shorter duration than LSD.^[2][10] For comparison, LAE-32, has a dose range of 0.5 to 1.6 mg, about 5 to 10% of the activity of LSD, and a likewise faster onset and shorter duration than LSD.^[1][2][3][9] Both ALA-10 and LAE-32 are said to produce only slight or weak hallucinogenic effects.^[11] ALA-10 is around 15-fold less potent than ALD-52 (1-acetyl-LSD), which is roughly equipotent with LSD.^[1][2][3]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Pharmacology

Pharmacodynamics

ALA-10 shows antiserotonergic activity in the isolated rat uterus of about 39% of that of LSD but about 3 times stronger than that of LAE-32.^[1][10] Its pyretogenic potency in rabbits is only about 1% of that of LSD.^[1]

History

ALA-10 was first described in the scientific literature by the late 1950s.^[1][10]

See also

• Substituted lysergamide
• MLA-74 (1-methyl-LAE)
• ALD-52 (1-acetyl-LSD; 1A-LSD)