ALDH16A1

Aldehyde dehydrogenase 16 family, member A1 also known as ALDH16A1 is an aldehyde dehydrogenase gene.

ALDH16A1
Identifiers
Aliases	ALDH16A1, aldehyde dehydrogenase 16 family member A1
External IDs	OMIM: 613358; MGI: 1916998; HomoloGene: 34938; GeneCards: ALDH16A1; OMA:ALDH16A1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,453,225 bp[1] End 49,471,050 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 44,790,108 bp[2] End 44,804,008 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen mucosa of transverse colon canal of the cervix ectocervix apex of heart right lobe of liver body of pancreas right adrenal gland skin of leg Top expressed in duodenum right kidney proximal tubule jejunum granulocyte epithelium of small intestine crypt of lieberkuhn of small intestine interventricular septum internal carotid artery ileum More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity aldehyde dehydrogenase (NAD+) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Cellular component extracellular exosome membrane Biological process metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 126133 69748 Ensembl ENSG00000161618 ENSMUSG00000007833 UniProt Q8IZ83 Q571I9 RefSeq (mRNA) NM_001145396 NM_153329 NM_145954 RefSeq (protein) NP_001138868 NP_699160 NP_666066 Location (UCSC) Chr 19: 49.45 – 49.47 Mb Chr 7: 44.79 – 44.8 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

Mutations in the SPG21 (ACP33/maspardin) gene are associated with the mast syndrome, a type of spastic paraplegia. The protein encoded by the SPG21 gene has been shown to interact with the ALDH16A1 enzyme.^[5]