ALG10

Alpha-1,2-glucosyltransferase ALG10-A is an enzyme that in humans is encoded by the ALG10 gene.^[5] It is a member of the Dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase class of enzymes.

ALG10
Identifiers
Aliases	ALG10, ALG10A, DIE2, KCR1, alpha-1,2-glucosyltransferase, ALG10 alpha-1,2-glucosyltransferase
External IDs	OMIM: 618355; MGI: 2146159; HomoloGene: 6030; GeneCards: ALG10; OMA:ALG10 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p11.1 Start 34,022,468 bp[1] End 34,029,694 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E3 Start 90,108,514 bp[2] End 90,117,674 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle bone marrow cell Achilles tendon islet of Langerhans stromal cell of endometrium secondary oocyte monocyte epithelium of colon appendix Top expressed in hand secondary oocyte superior cervical ganglion primary oocyte atrioventricular valve otolith organ trigeminal ganglion utricle endocardial cushion medial ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity transferase activity glycosyltransferase activity dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process protein glycosylation dolichol-linked oligosaccharide biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84920 380959 Ensembl ENSG00000139133 ENSMUSG00000075470 UniProt Q5BKT4 Q3UGP8 RefSeq (mRNA) NM_032834 NM_001033441 RefSeq (protein) NP_116223 NP_001028613 Location (UCSC) Chr 12: 34.02 – 34.03 Mb Chr 15: 90.11 – 90.12 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel.^[6]