ALG13

UDP-N-acetylglucosamine transferase subunit ALG13 homolog, also known as asparagine-linked glycosylation 13 homolog, is an enzyme that in humans is encoded by the ALG13 gene.^[5][6]

ALG13
Identifiers
Aliases	ALG13, CDG1S, CXorf45, GLT28D1, MDS031, TDRD13, YGL047W, EIEE36, UDP-N-acetylglucosaminyltransferase subunit, ALG13 UDP-N-acetylglucosaminyltransferase subunit, DEE36
External IDs	OMIM: 300776; MGI: 1914824; HomoloGene: 78772; GeneCards: ALG13; OMA:ALG13 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq23 Start 111,665,811 bp[1] End 111,760,649 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F2 Start 143,100,800 bp[2] End 143,157,446 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon right uterine tube endothelial cell mucosa of sigmoid colon canal of the cervix left ovary body of uterus anterior pituitary left uterine tube right ovary Top expressed in zygote morula primary oocyte secondary oocyte tail of embryo embryo yolk sac blastocyst spermatid genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function thiol-dependent deubiquitinase transferase activity peptidase activity cysteine-type peptidase activity hexosyltransferase activity protein binding catalytic activity hydrolase activity glycosyltransferase activity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity RNA binding Cellular component endoplasmic reticulum membrane endoplasmic reticulum UDP-N-acetylglucosamine transferase complex Biological process metabolism proteolysis dolichol-linked oligosaccharide biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79868 67574 Ensembl ENSG00000101901 ENSMUSG00000041718 UniProt Q9NP73 Q9D8C3 RefSeq (mRNA) NM_001039210 NM_001099922 NM_001168385 NM_001257230 NM_001257231 NM_001257234 NM_001257235 NM_001257237 NM_001257239 NM_001257240 NM_001257241 NM_018466 NM_001324290 NM_001324291 NM_001324292 NM_001324293 NM_001324294 NM_024810 NM_026247 RefSeq (protein) NP_001034299 NP_001093392 NP_001161857 NP_001244159 NP_001244160 NP_001244163 NP_001244164 NP_001244166 NP_001244168 NP_001244169 NP_001244170 NP_001311219 NP_001311220 NP_001311221 NP_001311222 NP_001311223 NP_060936 NP_080523 Location (UCSC) Chr X: 111.67 – 111.76 Mb Chr X: 143.1 – 143.16 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 (ALG14) homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation.^[5][7]

See also

• Congenital disorder of glycosylation