ACVR1C

The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene.^[5] ACVR1C is a type I receptor for the TGFB family of signaling molecules.^[5]

ACVR1C
Identifiers
Aliases	ACVR1C, ACVRLK7, ALK7, activin A receptor type 1C
External IDs	OMIM: 608981; MGI: 2661081; HomoloGene: 26724; GeneCards: ACVR1C; OMA:ACVR1C - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.1 Start 157,526,767 bp[1] End 157,628,864 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.1 Start 58,157,465 bp[2] End 58,247,907 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa adipose tissue secondary oocyte endothelial cell islet of Langerhans subcutaneous adipose tissue testicle buccal mucosa cell lactiferous gland abdominal fat Top expressed in brown adipose tissue white adipose tissue intercostal muscle subcutaneous adipose tissue Paneth cell dorsal striatum lumbar subsegment of spinal cord substantia nigra mammary gland nucleus accumbens More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity activin receptor activity, type I nucleotide binding protein kinase activity growth factor binding metal ion binding kinase activity transmembrane receptor protein serine/threonine kinase activity nodal binding ATP binding protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I SMAD binding activin binding Cellular component integral component of membrane membrane plasma membrane activin receptor complex integral component of plasma membrane receptor complex Biological process response to dietary excess cell differentiation negative regulation of insulin secretion phosphorylation lipid storage response to glucose negative regulation of trophoblast cell migration nodal signaling pathway response to insulin protein phosphorylation positive regulation of cysteine-type endopeptidase activity involved in apoptotic process transmembrane receptor protein serine/threonine kinase signaling pathway apoptotic nuclear changes negative regulation of chorionic trophoblast cell proliferation apoptotic process transforming growth factor beta receptor signaling pathway pattern specification process activin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 130399 269275 Ensembl ENSG00000123612 ENSMUSG00000026834 UniProt Q8NER5 Q8K348 RefSeq (mRNA) NM_145259 NM_001111031 NM_001111032 NM_001111033 NM_001033369 NM_001111030 RefSeq (protein) NP_001104501 NP_001104502 NP_001104503 NP_660302 NP_001028541 NP_001104500 Location (UCSC) Chr 2: 157.53 – 157.63 Mb Chr 2: 58.16 – 58.25 Mb PubMed search [3] [4]
Wikidata
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ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACVR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.^[6]

Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.^[5]