ALOX15B

Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene.^[5][6] ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1.

ALOX15B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NRE
Identifiers
Aliases	ALOX15B, 15-LOX-2, arachidonate 15-lipoxygenase, type B, arachidonate 15-lipoxygenase type B
External IDs	OMIM: 603697; MGI: 1098228; HomoloGene: 886; GeneCards: ALOX15B; OMA:ALOX15B - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 8,039,034 bp[1] End 8,049,134 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 69,074,758 bp[2] End 69,088,669 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of arm vulva prostate right lung nipple vagina skin of abdomen upper lobe of lung upper lobe of left lung Top expressed in lip dentate gyrus of hippocampal formation granule cell embryo hair follicle skin of external ear superior frontal gyrus primary visual cortex otic vesicle cerebellar cortex skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding calcium ion binding dioxygenase activity metal ion binding arachidonate 8(S)-lipoxygenase activity linoleate 13S-lipoxygenase activity oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen lipid binding arachidonate 15-lipoxygenase activity Cellular component intracellular anatomical structure extracellular exosome extrinsic component of membrane cytosol nucleus membrane cytoskeleton plasma membrane cytoplasm Biological process apoptotic process linoleic acid metabolic process negative regulation of growth lipid metabolism positive regulation of keratinocyte differentiation negative regulation of cell cycle prostate gland development lipoxygenase pathway hepoxilin biosynthetic process positive regulation of macrophage derived foam cell differentiation negative regulation of cell migration positive regulation of peroxisome proliferator activated receptor signaling pathway regulation of epithelial cell differentiation negative regulation of cell population proliferation arachidonic acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 247 11688 Ensembl ENSG00000179593 ENSMUSG00000020891 UniProt O15296 O35936 RefSeq (mRNA) NM_001141 NM_001039130 NM_001039131 NM_009661 RefSeq (protein) NP_001034219 NP_001034220 NP_001132 NP_033791 Location (UCSC) Chr 17: 8.04 – 8.05 Mb Chr 11: 69.07 – 69.09 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and 12-lipoxygenase and 44% amino acid sequence identity to human 5-lipoxygenase.^[5] 15-LOX-2 converts arachidonic acid almost exclusively to the S stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the S stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases; it metabolizes linoleic acid less effectively, converting this fatty acid to the S stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly reduced to the S stereoisomer of 13-Hydroxyoctadecadienoic acid.^[5] The ALOX15B gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.^[6]

See also

• Arachidonate 15-lipoxygenase
• 15-hydroxyicosatetraenoic acid
• ALOX15