ALPK1

Alpha-protein kinase 1 is an enzyme that in humans is encoded by the ALPK1 gene.^[5][6][7]

ALPK1
Identifiers
Aliases	ALPK1, 8430410J10Rik, LAK, alpha kinase 1, ROSAH
External IDs	OMIM: 607347; MGI: 1918731; HomoloGene: 11849; GeneCards: ALPK1; OMA:ALPK1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q25 Start 112,285,509 bp[1] End 112,442,621 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G2 Start 127,463,959 bp[2] End 127,574,176 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell tendon of biceps brachii blood pancreatic ductal cell monocyte Achilles tendon gastric mucosa spleen sural nerve skin of abdomen Top expressed in granulocyte ventricular zone spermatid esophagus embryo genital tubercle dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity ATP binding kinase activity protein serine/threonine kinase activity protein binding monosaccharide binding Cellular component cytoplasm cytosol Biological process protein phosphorylation phosphorylation immune system process cytoplasmic pattern recognition receptor signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80216 71481 Ensembl ENSG00000073331 ENSMUSG00000028028 UniProt Q96QP1 Q9CXB8 RefSeq (mRNA) NM_001102406 NM_001253884 NM_025144 NM_027808 RefSeq (protein) NP_001095876 NP_001240813 NP_079420 n/a Location (UCSC) Chr 4: 112.29 – 112.44 Mb Chr 3: 127.46 – 127.57 Mb PubMed search [3] [4]
Wikidata
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Unlike most eukaryotic kinases, alpha kinases, such as LAK, recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.[supplied by OMIM]^[7]