ALPPL2

Alkaline phosphatase, placental-like 2 is a protein that in humans is encoded by the ALPPL2 gene.^[5]

ALPG
Identifiers
Aliases	ALPG, GCAP, ALPPL2, alkaline phosphatase, placental like 2, alkaline phosphatase, germ cell, ALPPL
External IDs	OMIM: 171810; MGI: 108009; HomoloGene: 129600; GeneCards: ALPG; OMA:ALPG - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 232,406,844 bp[1] End 232,410,714 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C5|1 44.05 cM Start 87,014,416 bp[2] End 87,017,650 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad mucosa of colon placenta right uterine tube mucosa of transverse colon lower respiratory tract lung right lung endometrium Top expressed in morula morula blastocyst secondary oocyte perirhinal cortex entorhinal cortex choroid plexus of fourth ventricle primary oocyte CA3 field spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatase activity catalytic activity hydrolase activity metal ion binding alkaline phosphatase activity Cellular component anchored component of membrane membrane extracellular region plasma membrane Biological process metabolism dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 251 11650 Ensembl ENSG00000163286 ENSMUSG00000026246 UniProt P10696 P24823 RefSeq (mRNA) NM_031313 NM_007433 RefSeq (protein) NP_112603 NP_031459 Location (UCSC) Chr 2: 232.41 – 232.41 Mb Chr 1: 87.01 – 87.02 Mb PubMed search [3] [4]
Wikidata
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Function

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase.^[5]