AMFR

Autocrine motility factor receptor, isoform 2 is a protein that in humans is encoded by the AMFR gene.^[5][6]

AMFR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EJS, 2LVN, 2LVO, 2LVP, 2LVQ, 2LXH, 2LXP, 3FSH, 3H8K, 3TIW, 4G3O, 4LAD
Identifiers
Aliases	AMFR, GP78, RNF45, autocrine motility factor receptor
External IDs	OMIM: 603243; MGI: 1345634; HomoloGene: 888; GeneCards: AMFR; OMA:AMFR - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q13 Start 56,361,452 bp[1] End 56,425,545 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C5|8 45.96 cM Start 94,698,216 bp[2] End 94,739,470 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right testis left testis gastrocnemius muscle muscle of thigh right adrenal cortex Achilles tendon ventricular zone left adrenal gland left adrenal cortex Top expressed in spermatocyte Ileal epithelium spermatid secondary oocyte granulocyte decidua ankle dentate gyrus of hippocampal formation granule cell triceps brachii muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity chaperone binding ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity ubiquitin-ubiquitin ligase activity protein binding ubiquitin-specific protease binding transferase activity identical protein binding BAT3 complex binding signaling receptor activity Cellular component cytoplasm integral component of membrane membrane growth cone integral component of endoplasmic reticulum membrane soma dendrite Derlin-1 retrotranslocation complex perinuclear region of cytoplasm nucleus endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus endoplasmic reticulum quality control compartment protein-containing complex ubiquitin ligase complex cytosol Biological process ERAD pathway ubiquitin-dependent protein catabolic process ageing protein polyubiquitination endoplasmic reticulum unfolded protein response protein K48-linked ubiquitination protein complex oligomerization protein ubiquitination ubiquitin-dependent ERAD pathway learning or memory positive regulation of protein binding signal transduction protein autoubiquitination protein folding endoplasmic reticulum mannose trimming Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 267 23802 Ensembl ENSG00000159461 ENSMUSG00000031751 UniProt Q9UKV5 Q9R049 RefSeq (mRNA) NM_001144 NM_138958 NM_001323511 NM_001323512 NM_011787 RefSeq (protein) NP_001135 NP_001310440 NP_001310441 NP_035917 Location (UCSC) Chr 16: 56.36 – 56.43 Mb Chr 8: 94.7 – 94.74 Mb PubMed search [3] [4]
Wikidata
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Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells.^[6]

Interactions

AMFR has been shown to interact with Valosin-containing protein.^[7][8]