AMY1C

The human AMY1C gene encodes the protein Amylase, alpha 1C (salivary). ^[3]

AMY1C
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1C8Q, 1JXJ, 1JXK, 1MFU, 1MFV, 1NM9, 1Q4N, 1SMD, 1XV8, 1Z32, 3BLK, 3BLP, 3DHP
Identifiers
Aliases	AMY1C, AMY1, amylase, alpha 1C (salivary), amylase alpha 1C (salivary), amylase alpha 1C
External IDs	OMIM: 104702; HomoloGene: 133998; GeneCards: AMY1C; OMA:AMY1C - orthologs
EC number	3.2.1.1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p21.1 Start 103,745,323 bp[1] End 103,758,726 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube testicle olfactory zone of nasal mucosa gonad right lobe of thyroid gland left lobe of thyroid gland body of pancreas right lung upper lobe of left lung left testis n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding alpha-amylase activity hydrolase activity catalytic activity metal ion binding hydrolase activity, acting on glycosyl bonds cation binding Cellular component extracellular region extracellular exosome extracellular space Biological process digestion metabolism carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 278 n/a Ensembl ENSG00000187733 n/a UniProt P04745 n/a RefSeq (mRNA) NM_001008219 NM_001346780 n/a RefSeq (protein) NP_001008220 NP_001333709 NP_001008222 NP_004029 NP_001008219 n/a Location (UCSC) Chr 1: 103.75 – 103.76 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either the salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland.^[4] See also Amylase § Evolution.