AMY2B

Alpha-amylase 2B is an enzyme that in humans is encoded by the AMY2B gene.^[5][6]

AMY2B
Identifiers
Aliases	AMY2B, AMY2, AMY3, HXA, amylase, alpha 2B (pancreatic), amylase alpha 2B (pancreatic), amylase alpha 2B
External IDs	OMIM: 104660; MGI: 3714985; HomoloGene: 134663; GeneCards: AMY2B; OMA:AMY2B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p21.1 Start 103,553,815 bp[1] End 103,579,534 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F3|3 Start 113,219,771 bp[2] End 113,231,368 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right uterine tube cerebellar hemisphere right hemisphere of cerebellum gastric mucosa left lobe of thyroid gland tibial nerve right lobe of thyroid gland apex of heart Achilles tendon Top expressed in pancreas islet of Langerhans stomach colon esophagus duodenum jejunum quadriceps femoris muscle spermatid ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function catalytic activity alpha-amylase activity hydrolase activity metal ion binding hydrolase activity, acting on glycosyl bonds cation binding Cellular component extracellular region extracellular exosome Biological process digestion metabolism carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 280 100043686 Ensembl ENSG00000240038 ENSMUSG00000093931 UniProt P19961 P00688 RefSeq (mRNA) NM_020978 NM_001386109 NM_001387437 NM_001160151 RefSeq (protein) NP_066188 NP_001036176 NP_001153622 NP_001153623 NP_001153624 Location (UCSC) Chr 1: 103.55 – 103.58 Mb Chr 3: 113.22 – 113.23 Mb PubMed search [3] [4]
Wikidata
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Function

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside] bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.^[6]