ANGPT4

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.^[5][6][7]

ANGPT4
Identifiers
Aliases	ANGPT4, AGP4, ANG-3, ANG4, ANG3, angiopoietin 4
External IDs	OMIM: 603705; MGI: 1336887; HomoloGene: 36302; GeneCards: ANGPT4; OMA:ANGPT4 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 869,900 bp[1] End 916,334 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 G3|2 74.83 cM Start 151,753,130 bp[2] End 151,787,257 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in subcutaneous adipose tissue left uterine tube right ovary canal of the cervix popliteal artery tibial arteries body of uterus left ovary ectocervix right coronary artery Top expressed in decidua stroma of bone marrow gastrula body of femur lip molar efferent ductule vas deferens skin of external ear abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor tyrosine kinase binding transmembrane receptor protein tyrosine kinase activator activity Cellular component extracellular region extracellular space Biological process Notch signaling pathway positive regulation of endothelial cell migration negative regulation of angiogenesis negative regulation of apoptotic process negative regulation of blood vessel endothelial cell migration cellular response to hypoxia endothelial cell proliferation angiogenesis positive regulation of blood vessel endothelial cell migration leukocyte migration positive regulation of angiogenesis positive regulation of peptidyl-tyrosine phosphorylation activation of transmembrane receptor protein tyrosine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51378 11602 Ensembl ENSG00000101280 ENSMUSG00000027460 UniProt Q9Y264 Q9WVH6 RefSeq (mRNA) NM_015985 NM_001322809 NM_009641 RefSeq (protein) NP_001309738 NP_057069 NP_033771 Location (UCSC) Chr 20: 0.87 – 0.92 Mb Chr 2: 151.75 – 151.79 Mb PubMed search [3] [4]
Wikidata
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Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells.

The protein encoded by this gene functions as an agonist and is an angiopoietin.^[7]