Aldehyde oxidase 1

Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene.^[5][6]

AOX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UHW, 4UHX, 5EPG
Identifiers
Aliases	AOX1, AO, AOH1, aldehyde oxidase 1
External IDs	OMIM: 602841; MGI: 88035; HomoloGene: 68165; GeneCards: AOX1; OMA:AOX1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.1 Start 200,586,014 bp[1] End 200,677,064 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C1.3|1 28.86 cM Start 58,069,090 bp[2] End 58,145,572 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal cortex right lobe of liver body of pancreas left uterine tube germinal epithelium subcutaneous adipose tissue right ovary kidney tubule gastric mucosa Top expressed in left lobe of liver tunica adventitia of aorta lumbar spinal ganglion brown adipose tissue soleus muscle tunica media of zone of aorta white adipose tissue facial motor nucleus esophagus intercostal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity, acting on CH-OH group of donors iron-sulfur cluster binding NAD binding metal ion binding catalytic activity electron transfer activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors aldehyde oxidase activity iron ion binding protein homodimerization activity molybdopterin cofactor binding flavin adenine dinucleotide binding 2 iron, 2 sulfur cluster binding identical protein binding xanthine dehydrogenase activity FAD binding Cellular component extracellular exosome cytoplasm cytosol nuclear body Biological process xanthine catabolic process vitamin B6 metabolic process electron transport chain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 316 11761 Ensembl ENSG00000138356 ENSMUSG00000063558 UniProt Q06278 O54754 RefSeq (mRNA) NM_001159 NM_009676 RefSeq (protein) NP_001150 NP_033806 Location (UCSC) Chr 2: 200.59 – 200.68 Mb Chr 1: 58.07 – 58.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide.^[5]

Clinical significance

Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis.^[6]

See also

• MOCOS