MOCOS

"Molybdenum cofactor sulfurase" redirects here. For the similar enzyme in plants also sometimes called Molybdenum cofactor sulfurase, see Molybdenum cofactor sulfurtransferase.

Molybdenum cofactor sulfurase is an enzyme that in humans is encoded by the MOCOS gene.^[5][6]

MOCOS
Identifiers
Aliases	MOCOS, hMCS, MCS, MOS, molybdenum cofactor sulfurase
External IDs	OMIM: 613274; MGI: 1915841; HomoloGene: 9931; GeneCards: MOCOS; OMA:MOCOS - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.2 Start 36,187,497 bp[1] End 36,272,157 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A2 Start 24,786,748 bp[2] End 24,834,632 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte right lobe of liver palpebral conjunctiva right adrenal gland right adrenal cortex jejunal mucosa left adrenal gland left adrenal cortex buccal mucosa cell duodenum Top expressed in granulocyte left lobe of liver esophagus primary oocyte jejunum gastrula respiratory epithelium olfactory system olfactory epithelium duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity molybdenum ion binding pyridoxal phosphate binding protein binding catalytic activity Mo-molybdopterin cofactor sulfurase activity molybdenum cofactor sulfurtransferase activity lyase activity Cellular component cytosol cellular component Biological process Mo-molybdopterin cofactor biosynthetic process molybdopterin cofactor biosynthetic process molybdopterin cofactor metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55034 68591 Ensembl ENSG00000075643 ENSMUSG00000039616 UniProt Q96EN8 Q14CH1 RefSeq (mRNA) NM_017947 NM_026779 RefSeq (protein) NP_060417 NP_081055 Location (UCSC) Chr 18: 36.19 – 36.27 Mb Chr 18: 24.79 – 24.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH) and aldehyde oxidase (AOX1), which is required for their enzymatic activities.^[5]