AP1G2

AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene.^[5][6][7]

AP1G2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E9G, 2YMT, 3ZHF, 4BCX
Identifiers
Aliases	AP1G2, G2AD, adaptor related protein complex 1 gamma 2 subunit, adaptor related protein complex 1 subunit gamma 2
External IDs	OMIM: 603534; MGI: 1328307; HomoloGene: 49141; GeneCards: AP1G2; OMA:AP1G2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 23,559,565 bp[1] End 23,568,070 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 55,336,032 bp[2] End 55,344,050 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum granulocyte anterior pituitary right uterine tube right lobe of thyroid gland left lobe of thyroid gland right frontal lobe left ovary right ovary mucosa of transverse colon Top expressed in duodenum yolk sac granulocyte jejunum otic vesicle lip ileum crypt of lieberkuhn of small intestine otic placode thymus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component Golgi-associated vesicle membrane coat Golgi membrane endosome Golgi apparatus endosome membrane transport vesicle membrane cytoplasmic vesicle membrane cytoplasmic vesicle clathrin adaptor complex AP-1 adaptor complex Biological process protein transport intracellular protein transport viral process vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8906 11766 Ensembl ENSG00000213983 ENSMUSG00000040701 UniProt O75843 O88512 RefSeq (mRNA) NM_001282474 NM_001282475 NM_003917 NM_080545 NM_001354673 NM_001354674 NM_001354675 NM_001354677 NM_001354681 NM_007455 NM_001303502 RefSeq (protein) NP_001269403 NP_001269404 NP_003908 NP_001341602 NP_001341603 NP_001341604 NP_001341606 NP_001341610 NP_001290431 NP_031481 Location (UCSC) Chr 14: 23.56 – 23.57 Mb Chr 14: 55.34 – 55.34 Mb PubMed search [3] [4]
Wikidata
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Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. There are two alternatively spliced transcript variants of this gene encoding the same protein.^[7]

Interactions

AP1G2 has been shown to interact with NEDD4.^[8]