AP2S1

AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene.^[5][6][7]

AP2S1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JKR, 2JKT, 2VGL, 2XA7, 4UQI, 4NEE
Identifiers
Aliases	AP2S1, AP17, CLAPS2, FBH3, FBHOk, HHC3, adaptor related protein complex 2 sigma 1 subunit, adaptor related protein complex 2 subunit sigma 1
External IDs	OMIM: 602242; MGI: 2141861; HomoloGene: 3001; GeneCards: AP2S1; OMA:AP2S1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 46,838,136 bp[1] End 46,850,846 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A2 Start 16,472,335 bp[2] End 16,483,219 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right adrenal gland right frontal lobe mucosa of transverse colon human penis right adrenal cortex left adrenal gland left adrenal cortex prefrontal cortex cingulate gyrus Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus granulocyte facial motor nucleus neural tube ventricular zone yolk sac lip stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity clathrin adaptor activity protein binding Cellular component endocytic vesicle membrane cytosol clathrin-coated endocytic vesicle membrane membrane plasma membrane endolysosome membrane membrane coat clathrin-coated pit AP-2 adaptor complex clathrin-coated endocytic vesicle intracellular membrane-bounded organelle Biological process regulation of endocytosis endocytosis antigen processing and presentation of exogenous peptide antigen via MHC class II ephrin receptor signaling pathway mitigation of host defenses by virus clathrin-dependent endocytosis clathrin coat assembly protein transport intracellular protein transport vesicle-mediated transport microtubule-based movement Wnt signaling pathway, planar cell polarity pathway membrane organization low-density lipoprotein particle receptor catabolic process low-density lipoprotein particle clearance transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1175 232910 Ensembl ENSG00000042753 ENSMUSG00000008036 UniProt P53680 P62743 RefSeq (mRNA) NM_001301076 NM_001301078 NM_001301081 NM_004069 NM_021575 NM_198613 RefSeq (protein) NP_001288005 NP_001288007 NP_001288010 NP_004060 NP_067586 NP_941015 Location (UCSC) Chr 19: 46.84 – 46.85 Mb Chr 7: 16.47 – 16.48 Mb PubMed search [3] [4]
Wikidata
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One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.^[7]