AP3D1

AP-3 complex subunit delta-1 is a protein that in humans is encoded by the AP3D1 gene.^[5][6][7]

AP3D1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AFI
Identifiers
Aliases	AP3D1, ADTD, hBLVR, adaptor related protein complex 3 delta 1 subunit, HPS10, adaptor related protein complex 3 subunit delta 1
External IDs	OMIM: 607246; MGI: 107734; HomoloGene: 2926; GeneCards: AP3D1; OMA:AP3D1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,100,988 bp[1] End 2,164,468 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 80,542,790 bp[2] End 80,578,098 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii anterior pituitary lateral nuclear group of thalamus parotid gland beta cell cerebellar vermis stromal cell of endometrium pylorus pars compacta frontal pole Top expressed in Ileal epithelium vestibular membrane of cochlear duct anterior amygdaloid area ventromedial nucleus facial motor nucleus arcuate nucleus habenula subiculum medial dorsal nucleus lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity Cellular component cytoplasm Golgi apparatus membrane Golgi membrane axon lysosomal membrane terminal bouton membrane coat endosome membrane axon cytoplasm AP-3 adaptor complex presynaptic endosome plasma membrane presynapse postsynapse glutamatergic synapse Biological process protein localization to organelle protein localization to membrane antigen processing and presentation eye pigment biosynthetic process anterograde axonal transport melanosome organization synaptic vesicle membrane organization endosome to melanosome transport protein transport regulation of sequestering of zinc ion antigen processing and presentation, exogenous lipid antigen via MHC class Ib positive regulation of NK T cell differentiation anterograde synaptic vesicle transport intracellular protein transport vesicle-mediated transport synaptic vesicle budding from endosome neurotransmitter receptor transport, postsynaptic endosome to lysosome transport protein targeting to vacuole Golgi to vacuole transport vesicle-mediated transport in synapse Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8943 11776 Ensembl ENSG00000065000 ENSMUSG00000020198 UniProt O14617 O54774 RefSeq (mRNA) NM_001077523 NM_001261826 NM_003938 NM_001374799 NM_007460 RefSeq (protein) NP_001248755 NP_003929 NP_001361728 NP_031486 Location (UCSC) Chr 19: 2.1 – 2.16 Mb Chr 10: 80.54 – 80.58 Mb PubMed search [3] [4]
Wikidata
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Function

AP3D1 is a subunit of the AP3 adaptor-like complex, which is not associated with clathrin. The AP3D1 subunit is implicated in intracellular biogenesis and trafficking of pigment granules and possibly platelet dense granules and neurotransmitter vesicles.[supplied by OMIM]^[7]

Interactions

AP3D1 has been shown to interact with SYBL1.^[8]