APBA1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

APBA1

Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene.[5][6][7]

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APBA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPBA1, D9S411E, LIN10, MINT1, X11, X11A, X11ALPHA, amyloid beta precursor protein binding family A member 1
External IDsOMIM: 602414; MGI: 1860297; HomoloGene: 897; GeneCards: APBA1; OMA:APBA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001163

NM_177034

RefSeq (protein)

NP_001154

NP_796008

Location (UCSC)Chr 9: 69.43 – 69.67 MbChr 19: 23.74 – 23.93 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.[7]

Interactions

APBA1 has been shown to interact with KCNJ12,[8][9] CCS,[10] CASK[11][12] and Amyloid precursor protein.[13][14]

References

Further reading

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