APBA3

Amyloid beta A4 precursor protein-binding family A member 3 is a protein that in humans is encoded by the APBA3 gene.^[5][6]

APBA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YT7, 2YT8
Identifiers
Aliases	APBA3, MGC:15815, X11L2, mint3, amyloid beta precursor protein binding family A member 3
External IDs	OMIM: 604262; MGI: 1888527; HomoloGene: 3591; GeneCards: APBA3; OMA:APBA3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,750,772 bp[1] End 3,761,692 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 81,102,794 bp[2] End 81,109,080 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell granulocyte right hemisphere of cerebellum right ovary left ovary blood spleen cartilage tissue lymph node gastrocnemius muscle Top expressed in muscle of thigh skeletal muscle tissue adrenal gland spermatocyte yolk sac quadriceps femoris muscle proximal tubule right kidney esophagus white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme binding enzyme inhibitor activity amyloid-beta binding protein binding Cellular component cytoplasm perinuclear region of cytoplasm plasma membrane dendritic spine synapse Biological process protein transport regulation of catalytic activity negative regulation of catalytic activity in utero embryonic development chemical synaptic transmission regulation of gene expression Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9546 57267 Ensembl ENSG00000011132 ENSMUSG00000004931 UniProt O96018 O88888 RefSeq (mRNA) NM_004886 NM_018758 RefSeq (protein) NP_004877 NP_061228 Location (UCSC) Chr 19: 3.75 – 3.76 Mb Chr 10: 81.1 – 81.11 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.^[6]

Interactions

APBA3 has been shown to interact with Amyloid precursor protein.^[5][7]