API5

The human gene API5 encodes the protein Apoptosis inhibitor 5.^[5][6]

API5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3U0R, 3V6A
Identifiers
Aliases	API5, AAC-11, AAC11, apoptosis inhibitor 5
External IDs	OMIM: 609774; MGI: 1888993; HomoloGene: 4809; GeneCards: API5; OMA:API5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p12 Start 43,311,963 bp[1] End 43,344,529 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 94,242,027 bp[2] End 94,268,481 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans rectum ventricular zone superficial temporal artery oocyte parotid gland endometrium ganglionic eminence mucosa of paranasal sinus cecum Top expressed in primitive streak cumulus cell external carotid artery maxillary prominence retinal pigment epithelium ureter ciliary body lacrimal gland internal carotid artery conjunctival fornix More reference expression data BioGPS n/a
Gene ontology Molecular function fibroblast growth factor binding protein binding RNA binding Cellular component cytoplasm spliceosomal complex membrane nucleus nuclear speck Biological process negative regulation of fibroblast apoptotic process negative regulation of apoptotic process apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8539 11800 Ensembl ENSG00000166181 ENSMUSG00000027193 UniProt Q9BZZ5 O35841 RefSeq (mRNA) NM_001142930 NM_001142931 NM_001243747 NM_006595 NM_007466 NM_001305258 NM_001349003 RefSeq (protein) NP_001136402 NP_001136403 NP_001230676 NP_006586 NP_001292187 NP_031492 NP_001335932 Location (UCSC) Chr 11: 43.31 – 43.34 Mb Chr 2: 94.24 – 94.27 Mb PubMed search [3] [4]
Wikidata
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This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs. Crystal structure of API5 exhibited the function for protein-protein interaction ^[7]

Diseases associated with API5 include colon adenocarcinoma, and cervical cancer.

API5 functions in nuclear export of mRNA.^[8]