APLP1

Amyloid precursor like protein 1, also known as APLP1, is a protein encoded by the APLP1 gene in humans.^[5][6] APLP1 along with APLP2 are important modulators of glucose and insulin homeostasis.^[7]

APLP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PMR, 3Q7G, 3Q7L, 3QMK, 4RD9, 4RDA
Identifiers
Aliases	APLP1, APLP, amyloid beta precursor like protein 1
External IDs	OMIM: 104775; MGI: 88046; HomoloGene: 68447; GeneCards: APLP1; OMA:APLP1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 35,867,899 bp[1] End 35,879,792 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B1|7 18.32 cM Start 30,134,407 bp[2] End 30,144,960 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment inferior olivary nucleus middle frontal gyrus right frontal lobe prefrontal cortex caudate nucleus nucleus accumbens dorsal motor nucleus of vagus nerve Amygdala Hypothalamus Top expressed in nucleus accumbens nucleus of stria terminalis piriform cortex molar subiculum olfactory tubercle central gray substance of midbrain globus pallidus primary visual cortex superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function alpha-2C adrenergic receptor binding heparin binding alpha-2B adrenergic receptor binding metal ion binding protein binding alpha-2A adrenergic receptor binding identical protein binding transition metal ion binding Cellular component cytoplasm integral component of membrane membrane plasma membrane basement membrane perinuclear region of cytoplasm Biological process endocytosis nervous system development cellular response to norepinephrine stimulus cell adhesion animal organ morphogenesis apoptotic process negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 333 11803 Ensembl ENSG00000105290 ENSMUSG00000006651 UniProt P51693 Q03157 RefSeq (mRNA) NM_005166 NM_001024807 NM_007467 RefSeq (protein) NP_001019978 NP_005157 NP_031493 Location (UCSC) Chr 19: 35.87 – 35.88 Mb Chr 7: 30.13 – 30.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.^[5]

APLP1 and APLP2 double knockout mice display hypoglycemia and hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.^[7]

APLP1 has also been implicated in the transmission pathologic α-synuclein in Parkinson's disease^[8][9]