APOBEC3D

Probable DNA dC->dU-editing enzyme APOBEC-3D is a protein that in humans is encoded by the APOBEC3D gene.^[3][4]

APOBEC3D
Identifiers
Aliases	APOBEC3D, A3D, APOBEC3DE, APOBEC3E, ARP6, apolipoprotein B mRNA editing enzyme catalytic subunit 3D, A3DE
External IDs	OMIM: 609900; HomoloGene: 122788; GeneCards: APOBEC3D; OMA:APOBEC3D - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 39,021,113 bp[1] End 39,033,277 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node spleen bone marrow cells blood appendix right uterine tube monocyte gallbladder rectum n/a More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines zinc ion binding catalytic activity hydrolase activity metal ion binding RNA binding cytidine deaminase activity Cellular component cytoplasm P-body nucleus Biological process negative regulation of transposition innate immune response defense response to virus DNA cytosine deamination negative regulation of single stranded viral RNA replication via double stranded DNA intermediate immune system process cytidine deamination cytidine to uridine editing DNA demethylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140564 n/a Ensembl ENSG00000243811 n/a UniProt B2CML4 n/a RefSeq (mRNA) NM_152426 NM_001363781 n/a RefSeq (protein) NP_689639 NP_001350710 n/a Location (UCSC) Chr 22: 39.02 – 39.03 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA.^[4]