Cytidine deaminase

Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene.^[5][6][7]

CDA
Available structures PDB Ortholog search: A0A7K9BC85 PDBe A0A7K9BC85 RCSB List of PDB id codes 1MQ0
Identifiers
Aliases	CDA, CDD, cytidine deaminase
External IDs	OMIM: 123920; MGI: 1919519; HomoloGene: 1352; GeneCards: CDA; OMA:CDA - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 20,589,086 bp[1] End 20,618,903 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 138,065,735 bp[2] End 138,095,303 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood bone marrow right lobe of liver trabecular bone bone marrow cell testicle rectum skin of leg Top expressed in right kidney duodenum gastrula human kidney intestinal villus jejunum proximal tubule lumbar spinal ganglion facial motor nucleus endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity nucleoside binding cytidine deaminase activity zinc ion binding metal ion binding protein binding catalytic activity identical protein binding hydrolase activity Cellular component cytosol extracellular region secretory granule lumen tertiary granule lumen ficolin-1-rich granule lumen Biological process cytosine metabolic process pyrimidine nucleoside salvage cell surface receptor signaling pathway cytidine deamination negative regulation of cell growth pyrimidine-containing compound salvage negative regulation of nucleotide metabolic process protein homotetramerization neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 978 72269 Ensembl ENSG00000158825 ENSMUSG00000028755 UniProt P32320 P56389 RefSeq (mRNA) NM_001785 NM_028176 RefSeq (protein) NP_001776 NP_082452 Location (UCSC) Chr 1: 20.59 – 20.62 Mb Chr 4: 138.07 – 138.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.^[7] Most cytidine deaminases act on RNA, and the few that act on DNA require ssDNA.^[8]

A related activation-induced (cytidine) deaminase (AID) regulates antibody diversification, especially the process of somatic hypermutation.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".