APOL2

Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene.^[5][6][7]

APOL2
Identifiers
Aliases	APOL2, APOL-II, APOL3, apolipoprotein L2
External IDs	OMIM: 607252; MGI: 2444921; HomoloGene: 12785; GeneCards: APOL2; OMA:APOL2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 36,226,209 bp[1] End 36,239,954 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 77,631,998 bp[2] End 77,641,203 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii granulocyte apex of heart gallbladder anterior pituitary internal globus pallidus blood cerebellar hemisphere monocyte right frontal lobe Top expressed in lumbar subsegment of spinal cord bone marrow facial motor nucleus human fetus embryo substantia nigra spleen embryo granulocyte primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding lipid binding high-density lipoprotein particle binding Cellular component cytoplasm extracellular region endoplasmic reticulum membrane membrane Biological process multicellular organism development lipoprotein metabolic process lipid transport cholesterol metabolic process acute-phase response maternal process involved in female pregnancy lipid metabolism transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23780 239552 Ensembl ENSG00000128335 ENSMUSG00000056656 UniProt Q9BQE5 n/a RefSeq (mRNA) NM_030882 NM_145637 NM_001081970 NM_001357895 NM_001357896 RefSeq (protein) NP_112092 NP_663612 n/a Location (UCSC) Chr 22: 36.23 – 36.24 Mb Chr 15: 77.63 – 77.64 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the apolipoprotein L gene family and protein in this family are lipid-binding proteins. This gene encodes a 37.1 kDa protein and The protein sequence contains 337bp. Localization of this protein is mainly found in the cytosol, nucleoplasm and additionally, it is also seen in the Nuclear bodies.^[8] The involvement of this gene may affect in the movement of lipids and binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene.^[7]

Amino acid sequence

MNPESSIFIE DYLKYFQDQV SRENLLQLLT DDEAWNGFVA AAELPRDEAD ELRKALNKLA SHMVMKDKNR HDKDQQHRQW FLKEFPRLKR ELEDHIRKLR ALAEEVEQVH RGTTIANVVS NSVGTTSGIL TLLGLGLAPF TEGISFVLLD TGMGLGAAAA VAGITCSVVE LVNKLRARAQ ARNLDQSGTN VAKVMKEFVG GNTPNVLTLV DNWYQVTQGI GRNIRAIRRA RANPQLGAYA PPPHVIGRIS AEGGEQVERV VEGPAQAMSR GTMIVGAATG GILLLLDVVS LAYESKHLLE GAKSESAEEL KKRAQELEGK LNFLTKIHEM LQPGQDQ^[9][10]

Total amino acids: 337^[9]

Interactions

APOL2 has been shown to interact with:

• IFN-γ,^[11]
• CD81,^[12]
• TNF-α,^[13]
• Bcl-2,^[14]

Splice variants

ApoL2 has 5 splice variants,^[15]

• APOL2-001

This transcript has 6 exons, 12 domains and features are annotated, 263 variations are related this and maps to 35 oligo probes.

• APOL2-002

This transcript has 5 exons, 12 domains and features are annotated, 263 variations are related with this gene and maps to 37 oligo probes.

• APOL2-006

This transcript has 6 exons, is annotated with 3 domains and features, 62 variations are related with this gene and maps to 20 oligo probes.

• APOL2-008

This transcript has 6 exons, 12 domains and features are annotated, 331 variations are related with this gene and maps to 32 oligo probes.

• APOL2-009

This transcript has 5 exons, 4 domains and features are annotated, 104 variations are related with this gene and maps to 13 oligo probes.

Functions of the ApoL2

• Acute Inflammation Response ^[16][17]
• Cholesterol Metabolic Process^[18]
• Lipid Metabolic Process^[14]
• Maternal Process Involved in Female Pregnancy^[19]
• Lipid binding^[20]
• Signalling Receptor Binding^[20]
• Aging ^[21]