APOL3

Apolipoprotein L3 is a protein that in humans is encoded by the APOL3 gene.^[3][4] Expressed in the gut, it has antibiotic properties.^[5]

APOL3
Identifiers
Aliases	APOL3, APOLIII, CG121, CG12_1, apoL-III, apolipoprotein L3
External IDs	OMIM: 607253; HomoloGene: 129701; GeneCards: APOL3; OMA:APOL3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 36,140,330 bp[1] End 36,166,177 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte apex of heart gastric mucosa pericardium lymph node spleen subcutaneous adipose tissue right lung tendon of biceps brachii n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity lipid binding lipid transporter activity Cellular component cytoplasm extracellular region membrane Biological process lipoprotein metabolic process positive regulation of I-kappaB kinase/NF-kappaB signaling lipid transport inflammatory response signal transduction transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80833 n/a Ensembl ENSG00000128284 n/a UniProt O95236 n/a RefSeq (mRNA) NM_014349 NM_030644 NM_145639 NM_145640 NM_145641 NM_145642 n/a RefSeq (protein) NP_055164 NP_085147 NP_663614 NP_663615 NP_663616 NP_663617 n/a Location (UCSC) Chr 22: 36.14 – 36.17 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. In addition, expression of this gene is upregulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Six transcript variants encoding three different isoforms have been found for this gene.^[4]