ARFGEF2

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.^[5][6]

ARFGEF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L8N, 3SWV
Identifiers
Aliases	ARFGEF2, BIG2, PVNH2, dJ1164I10.1, ADP ribosylation factor guanine nucleotide exchange factor 2
External IDs	OMIM: 605371; MGI: 2139354; HomoloGene: 111880; GeneCards: ARFGEF2; OMA:ARFGEF2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.13 Start 48,921,711 bp[1] End 49,036,693 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 166,647,508 bp[2] End 166,739,972 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue jejunal mucosa parotid gland Epithelium of choroid plexus corpus epididymis skin of thigh cardia mucosa of sigmoid colon secondary oocyte retinal pigment epithelium Top expressed in retinal pigment epithelium lacrimal gland secondary oocyte submandibular gland Epithelium of choroid plexus stroma of bone marrow superior cervical ganglion epithelium of stomach interventricular septum medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanyl-nucleotide exchange factor activity GABA receptor binding myosin binding protein binding protein kinase A regulatory subunit binding Cellular component cytoplasm recycling endosome cytosol endosome Golgi apparatus cell projection membrane Golgi membrane dendritic spine synapse microtubule organizing center cell junction trans-Golgi network dendrite symmetric synapse asymmetric synapse perinuclear region of cytoplasm cytoskeleton cytoplasmic vesicle axonemal microtubule Biological process endomembrane system organization intracellular signal transduction regulation of ARF protein signal transduction endosome organization receptor recycling positive regulation of tumor necrosis factor production protein transport Golgi to plasma membrane transport exocytosis transport regulation of molecular function vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10564 99371 Ensembl ENSG00000124198 ENSMUSG00000074582 UniProt Q9Y6D5 A2A5R2 RefSeq (mRNA) NM_006420 NM_001085495 RefSeq (protein) NP_006411 NP_001078964 Location (UCSC) Chr 20: 48.92 – 49.04 Mb Chr 2: 166.65 – 166.74 Mb PubMed search [3] [4]
Wikidata
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Function

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.^[6]

Interactions

ARFGEF2 has been shown to interact with ARFGEF1,^[7] PRKAR1A^[8] and PRKAR2A.^[8]