ARG2

Arginase, type II is an arginase protein that in humans is encoded by the ARG2 gene.^[5]

ARG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PQ3, 4HZE, 4I06, 4IE2, 4IE3, 4IXU, 4IXV
Identifiers
Aliases	ARG2, arginase 2
External IDs	OMIM: 107830; MGI: 1330806; HomoloGene: 906; GeneCards: ARG2; OMA:ARG2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.1 Start 67,619,920 bp[1] End 67,651,708 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 79,177,551 bp[2] End 79,203,075 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii oocyte renal medulla human kidney secondary oocyte islet of Langerhans pituitary gland beta cell mucosa of paranasal sinus anterior pituitary Top expressed in duodenum granulocyte primary oocyte lobe of prostate jejunum zygote transitional epithelium of urinary bladder hair follicle secondary oocyte intestinal villus More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines arginase activity hydrolase activity metal ion binding manganese ion binding Cellular component mitochondrial matrix mitochondrion cytoplasm Biological process urea cycle ureteric bud development nitric oxide biosynthetic process striated muscle contraction arginine metabolic process negative regulation of type 2 immune response negative regulation of tumor necrosis factor production negative regulation of macrophage inflammatory protein 1 alpha production negative regulation of chemokine (C-C motif) ligand 4 production negative regulation of chemokine (C-C motif) ligand 5 production negative regulation of defense response to bacterium regulation of reactive oxygen species biosynthetic process negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of cellular senescence adaptive immune response immune system process innate immune response arginine catabolic process to ornithine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 384 11847 Ensembl ENSG00000081181 ENSMUSG00000021125 UniProt P78540 O08691 RefSeq (mRNA) NM_001172 NM_009705 RefSeq (protein) NP_001163 NP_033835 Location (UCSC) Chr 14: 67.62 – 67.65 Mb Chr 12: 79.18 – 79.2 Mb PubMed search [3] [4]
Wikidata
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Function

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II, this enzyme) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.