ARHGAP27

Rho GTPase activating protein 27 is a protein that in humans is encoded by the ARHGAP27 gene. ^[5]

ARHGAP27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PP2
Identifiers
Aliases	ARHGAP27, CAMGAP1, PP905, SH3D20, SH3P20, Rho GTPase activating protein 27
External IDs	OMIM: 610591; MGI: 1916903; HomoloGene: 45715; GeneCards: ARHGAP27; OMA:ARHGAP27 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 45,393,902 bp[1] End 45,434,421 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 103,222,323 bp[2] End 103,254,518 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood monocyte mucosa of transverse colon spleen duodenum appendix minor salivary glands vagina upper lobe of left lung Top expressed in granulocyte pyloric antrum otic vesicle esophagus right kidney gastric mucosa yolk sac epithelium of stomach lip fibula More reference expression data BioGPS n/a
Gene ontology Molecular function SH3 domain binding GTPase activator activity Cellular component intracellular anatomical structure membrane nucleus nucleoplasm cytoplasm cytosol Biological process endocytosis signal transduction positive regulation of GTPase activity receptor-mediated endocytosis regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 201176 544817 Ensembl ENSG00000159314 ENSG00000276836 ENSG00000276907 ENSMUSG00000034255 UniProt Q6ZUM4 Q8N2Y9 A2AB59 RefSeq (mRNA) NM_001159330 NM_001282290 NM_174919 NM_199282 NM_001205236 NM_133715 NM_183288 RefSeq (protein) NP_001269219 NP_777579 NP_954976 NP_954976.1 NP_001192165 NP_598476 NP_899111 Location (UCSC) Chr 17: 45.39 – 45.43 Mb Chr 11: 103.22 – 103.25 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may play a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013].