ARHGAP4

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene.^[5][6] It has been shown to regulate cell motility and axonal outgrowth in vitro.^[7]

ARHGAP4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2EPD
Identifiers
Aliases	ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115, Rho GTPase activating protein 4
External IDs	OMIM: 300023; MGI: 2159577; HomoloGene: 20403; GeneCards: ARHGAP4; OMA:ARHGAP4 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 153,907,367 bp[1] End 153,934,999 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 72,935,048 bp[2] End 72,965,476 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen monocyte lymph node blood right lung upper lobe of left lung appendix right hemisphere of cerebellum apex of heart Top expressed in granulocyte thymus spleen mesenteric lymph nodes blood tibiofemoral joint bone marrow subcutaneous adipose tissue otic vesicle embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity identical protein binding Cellular component cytosol Golgi apparatus growth cone microtubule cytoplasm Biological process negative regulation of fibroblast migration nervous system development positive regulation of GTPase activity negative regulation of cell migration cytoskeleton organization Rho protein signal transduction regulation of small GTPase mediated signal transduction negative regulation of axon extension signal transduction positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 393 171207 Ensembl ENSG00000089820 ENSMUSG00000031389 UniProt P98171 n/a RefSeq (mRNA) NM_001666 NM_001164741 NM_001162423 NM_001162424 NM_138630 RefSeq (protein) NP_001158213 NP_001657 n/a Location (UCSC) Chr X: 153.91 – 153.93 Mb Chr X: 72.94 – 72.97 Mb PubMed search [3] [4]
Wikidata
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