ARHGAP8

Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene.^[5][6]

ARHGAP8
Identifiers
Aliases	ARHGAP8, BPGAP1, PP610, Rho GTPase activating protein 8
External IDs	OMIM: 609405; MGI: 1920417; HomoloGene: 23645; GeneCards: ARHGAP8; OMA:ARHGAP8 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 44,752,558 bp[1] End 44,862,788 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E2 Start 84,604,253 bp[2] End 84,656,408 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left lobe of thyroid gland right lobe of thyroid gland mucosa of transverse colon body of pancreas minor salivary glands anterior pituitary spleen rectum human kidney Top expressed in seminal vesicula yolk sac parotid gland blastocyst vestibular membrane of cochlear duct zygote epithelium of stomach vestibular sensory epithelium secondary oocyte genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding GTPase activator activity Cellular component cytoplasm cytosol Biological process regulation of small GTPase mediated signal transduction signal transduction positive regulation of ERK1 and ERK2 cascade positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23779 73167 Ensembl ENSG00000241484 ENSMUSG00000078954 UniProt P85298 Q9CXP4 RefSeq (mRNA) NM_181335 NM_001017526 NM_001198726 NM_001164627 NM_001164628 NM_001205334 NM_028455 RefSeq (protein) NP_001017526 NP_001185655 NP_851852 NP_001158099 NP_001158100 NP_001192263 NP_082731 Location (UCSC) Chr 22: 44.75 – 44.86 Mb Chr 15: 84.6 – 84.66 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.^[6]