ARHGAP9

Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene.^[5][6]

ARHGAP9
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2P0D, 2P0H
Identifiers
Aliases	ARHGAP9, 10C, RGL1, Rho GTPase activating protein 9
External IDs	OMIM: 610576; MGI: 2143764; HomoloGene: 13041; GeneCards: ARHGAP9; OMA:ARHGAP9 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 57,472,264 bp[1] End 57,488,814 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 127,157,833 bp[2] End 127,165,812 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood spleen appendix monocyte lymph node bone marrow bone marrow cells trabecular bone mucosa of ileum Top expressed in granulocyte mesenteric lymph nodes blood thymus bone marrow spleen tibiofemoral joint submandibular gland parotid gland stroma of bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding phosphatidylinositol-3,4,5-trisphosphate binding lipid binding GTPase activator activity Cellular component cytosol extracellular region secretory granule lumen cytoplasm Biological process regulation of small GTPase mediated signal transduction signal transduction positive regulation of GTPase activity neutrophil degranulation regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64333 216445 Ensembl ENSG00000123329 ENSMUSG00000040345 UniProt Q9BRR9 n/a RefSeq (mRNA) NM_001080156 NM_001080157 NM_032496 NM_001319850 NM_001319851 NM_001319852 NM_001367422 NM_001367423 NM_001367424 NM_001367425 NM_001367426 NM_001285785 NM_146011 NM_001359656 NM_001359657 RefSeq (protein) NP_001073625 NP_001073626 NP_001306779 NP_001306780 NP_001306781 NP_115885 NP_001354351 NP_001354352 NP_001354353 NP_001354354 NP_001354355 NP_001306779.1 n/a Location (UCSC) Chr 12: 57.47 – 57.49 Mb Chr 10: 127.16 – 127.17 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene.^[6]