ARHGDIA

Rho GDP-dissociation inhibitor 1 is a protein that in humans is encoded by the ARHGDIA gene.^[5][6]

ARHGDIA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CC0, 1FSO, 1FST, 1FT0, 1FT3, 1HH4, 1KMT, 1QVY, 1RHO, 2BXW, 2JHS, 2JHT, 2JHU, 2JHV, 2JHW, 2JHX, 2JHY, 2JHZ, 2JI0, 2N80
Identifiers
Aliases	ARHGDIA, GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1, Rho GDP dissociation inhibitor alpha
External IDs	OMIM: 601925; MGI: 2178103; HomoloGene: 908; GeneCards: ARHGDIA; OMA:ARHGDIA - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 81,867,721 bp[1] End 81,871,378 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 120,468,930 bp[2] End 120,472,450 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte epithelium of colon mucosa of transverse colon left uterine tube upper lobe of left lung right lung ascending aorta left coronary artery tibial nerve anterior pituitary Top expressed in tail of embryo yolk sac genital tubercle tibiofemoral joint lip lactiferous gland entorhinal cortex mesenteric lymph nodes perirhinal cortex molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity Rho GDP-dissociation inhibitor activity protein binding Cellular component cytoplasm cytosol extracellular exosome cytoskeleton membrane Biological process negative regulation of cell adhesion regulation of actin cytoskeleton reorganization negative regulation of apoptotic process positive regulation of axonogenesis positive regulation of GTPase activity negative regulation of axonogenesis regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction semaphorin-plexin signaling pathway regulation of catalytic activity Rho protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 396 192662 Ensembl ENSG00000141522 ENSMUSG00000025132 UniProt P52565 Q99PT1 RefSeq (mRNA) NM_001185077 NM_001185078 NM_001301240 NM_001301241 NM_001301242 NM_001301243 NM_004309 NM_133796 NM_001363425 RefSeq (protein) NP_001172006 NP_001172007 NP_001288169 NP_001288170 NP_001288171 NP_001288172 NP_004300 NP_598557 NP_001350354 Location (UCSC) Chr 17: 81.87 – 81.87 Mb Chr 11: 120.47 – 120.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ARHGDIA has been shown to interact with:

• CDC42,^[7][8]
• RAC1,^{[7][8][9][10][11][12]}
• RHOA,^{[7][8][9][13][14]}
• Rac2,^[8][9] and
• RhoH.^[9][15]