ARHGEF2

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.^[5][6][7]

ARHGEF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5EFX
Identifiers
Aliases	ARHGEF2, GEF, GEF-H1, GEFH1, LFP40, P40, Rho/Rac guanine nucleotide exchange factor 2, NEDMHM, Lfc
External IDs	OMIM: 607560; MGI: 103264; HomoloGene: 3468; GeneCards: ARHGEF2; OMA:ARHGEF2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 155,946,851 bp[1] End 156,007,070 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 88,513,273 bp[2] End 88,555,359 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve ganglionic eminence corpus callosum C1 segment olfactory bulb blood granulocyte sural nerve upper lobe of left lung right lung Top expressed in spermatid seminiferous tubule superior frontal gyrus granulocyte dentate gyrus of hippocampal formation granule cell ventricular zone primary visual cortex neural layer of retina neural tube thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding zinc ion binding transcription factor binding metal ion binding protein binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm vesicle cytosol Golgi apparatus cell projection membrane focal adhesion bicellular tight junction spindle plasma membrane dendritic shaft ruffle membrane cell junction soma microtubule cytoskeleton cytoplasmic vesicle podosome postsynaptic density protein-containing complex glutamatergic synapse postsynaptic density, intracellular component Biological process intracellular signal transduction negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress negative regulation of necroptotic process actin filament organization immune system process negative regulation of neurogenesis cellular response to tumor necrosis factor cell division cellular response to muramyl dipeptide cellular hyperosmotic response negative regulation of microtubule depolymerization regulation of cell population proliferation positive regulation of NF-kappaB transcription factor activity negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cell morphogenesis establishment of mitotic spindle orientation positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of apoptotic process positive regulation of peptidyl-tyrosine phosphorylation cell cycle regulation of Rho protein signal transduction intracellular protein transport innate immune response regulation of small GTPase mediated signal transduction positive regulation of transcription by RNA polymerase II negative regulation of podosome assembly G protein-coupled receptor signaling pathway positive regulation of neuron differentiation asymmetric neuroblast division positive regulation of neuron migration multicellular organism development nervous system development cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9181 16800 Ensembl ENSG00000116584 ENSMUSG00000028059 UniProt Q92974 Q60875 RefSeq (mRNA) NM_001162383 NM_001162384 NM_004723 NM_001350110 NM_001350111 NM_001350112 NM_001198911 NM_001198912 NM_001198913 NM_008487 NM_001377126 RefSeq (protein) NP_001155855 NP_001155856 NP_004714 NP_001337039 NP_001337040 NP_001337041 NP_001185840 NP_001185841 NP_001185842 NP_032513 NP_001364055 Location (UCSC) Chr 1: 155.95 – 156.01 Mb Chr 3: 88.51 – 88.56 Mb PubMed search [3] [4]
Wikidata
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Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals.^[7]

Interactions

ARHGEF2 has been shown to interact with PAK1.^[8]