ARID3A

AT-rich interactive domain-containing protein 3A is a protein that in humans is encoded by the ARID3A gene.^[5][6]

ARID3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KK0, 4LJX
Identifiers
Aliases	ARID3A, BRIGHT, DRIL1, DRIL3, E2FBP1, AT-rich interaction domain 3A
External IDs	OMIM: 603265; MGI: 1328360; HomoloGene: 124247; GeneCards: ARID3A; OMA:ARID3A - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 925,781 bp[1] End 975,939 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 79,762,877 bp[2] End 79,790,852 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood placenta bone marrow cells left testis right testis stromal cell of endometrium buccal mucosa cell granulocyte sural nerve Top expressed in ovarian follicle granulocyte tibiofemoral joint tail of embryo yolk sac germinal epithelium gastrula genital tubercle ovarian follicle placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity DNA binding protein binding chromatin binding DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component membrane raft nucleus nucleoplasm cytoplasm cytosol intracellular membrane-bounded organelle Biological process positive regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1820 13496 Ensembl ENSG00000116017 ENSMUSG00000019564 UniProt Q99856 Q62431 RefSeq (mRNA) NM_005224 NM_001288625 NM_001288626 NM_007880 RefSeq (protein) NP_005215 NP_001275554 NP_001275555 NP_031906 Location (UCSC) Chr 19: 0.93 – 0.98 Mb Chr 10: 79.76 – 79.79 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification.^[6]

Interactions

ARID3A has been shown to interact with:

• BTK,^[7] and
• E2F1^[8]