ARID4A

AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a protein which in humans is encoded by the ARID4A gene.^[5][6][7]

ARID4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LCC, 2MAM, 2YRV
Identifiers
Aliases	ARID4A, RBBP-1, RBBP1, RBP-1, RBP1, AT-rich interaction domain 4A
External IDs	OMIM: 180201; MGI: 2444354; HomoloGene: 11303; GeneCards: ARID4A; OMA:ARID4A - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.1 Start 58,298,504 bp[1] End 58,373,887 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 71,015,990 bp[2] End 71,098,592 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve buccal mucosa cell epithelium of colon testicle monocyte ventricular zone bone marrow cell tendon of biceps brachii ganglionic eminence Top expressed in zygote tail of embryo hand granulocyte secondary oocyte genital tubercle blood aortic valve ascending aorta cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding histone deacetylase activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription repressor complex nucleus nucleoplasm cytosol plasma membrane Biological process histone H3-K9 trimethylation establishment of Sertoli cell barrier regulation of transcription, DNA-templated regulation of gene expression by genetic imprinting transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II erythrocyte development regulation of transcription by RNA polymerase II spermatogenesis histone H4-K20 trimethylation histone H3-K4 trimethylation transcription, DNA-templated negative regulation of transcription, DNA-templated histone deacetylation chromatin organization cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5926 238247 Ensembl ENSG00000032219 ENSMUSG00000048118 UniProt P29374 F8VPQ2 RefSeq (mRNA) NM_002892 NM_023000 NM_023001 NM_001081195 RefSeq (protein) NP_002883 NP_075376 NP_075377 NP_001074664 Location (UCSC) Chr 14: 58.3 – 58.37 Mb Chr 12: 71.02 – 71.1 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.^[5]

Interactions

ARID4A has been shown to interact with Retinoblastoma protein.^[8]