ARIH2

Protein ariadne-2 homolog is a protein that is encoded by the ARIH2 gene in humans.^[4][5]

ARIH2
Identifiers
Aliases	ARIH2, ARI2, TRIAD1, ariadne RBR E3 ubiquitin protein ligase 2
External IDs	OMIM: 605615; MGI: 1344361; HomoloGene: 48424; GeneCards: ARIH2; OMA:ARIH2 - orthologs
Gene location (Mouse) Chr. Chromosome 9 (mouse)[1] Band 9|9 F2 Start 108,480,141 bp[1] End 108,526,585 bp[1]
Gene ontology Molecular function ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity protein binding transferase activity ubiquitin conjugating enzyme binding zinc ion binding Cellular component cytoplasm nucleus nucleoplasm Cul5-RING ubiquitin ligase complex Biological process developmental cell growth positive regulation of protein targeting to mitochondrion protein K63-linked ubiquitination hematopoietic stem cell proliferation protein polyubiquitination multicellular organism development protein K48-linked ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10425 23807 Ensembl ENSG00000177479 ENSMUSG00000064145 UniProt O95376 Q9Z1K6 RefSeq (mRNA) NM_006321 NM_001317333 NM_001317334 NM_011790 NM_001357283 NM_001357285 NM_001357286 RefSeq (protein) NP_001304262 NP_001304263 NP_006312 NP_001336138 NP_001336139 NP_001336140 NP_001336141 NP_001336142 NP_001336143 NP_001336144 NP_001336145 NP_001336146 NP_001336147 NP_001336148 NP_001336149 NP_001336150 NP_001336151 NP_001336152 NP_001336153 NP_001336154 NP_001336155 NP_001336156 NP_001336157 NP_001336158 NP_001336159 NP_035920 NP_001344212 NP_001344214 NP_001344215 Location (UCSC) n/a Chr 9: 108.48 – 108.53 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Function

ARIH2 influences development of Mll-Ell-induced acute myeloid leukemia and regulates the proliferation,^[6] DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination,^[7] ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.^[8]