ARL3

ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene.^[5][6][7]

ARL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FZQ, 3BH6, 3BH7, 4GOJ
Identifiers
Aliases	ARL3, ARFL3, ADP ribosylation factor like GTPase 3, JBTS35, RP83
External IDs	OMIM: 604695; MGI: 1929699; HomoloGene: 48276; GeneCards: ARL3; OMA:ARL3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.32 Start 102,673,731 bp[1] End 102,714,397 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 46,519,535 bp[2] End 46,561,637 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell mucosa of paranasal sinus palpebral conjunctiva retinal pigment epithelium Pons pars compacta pars reticulata tibia epithelium of nasopharynx external globus pallidus Top expressed in neural layer of retina Epithelium of choroid plexus epithelium of lens retinal pigment epithelium motor neuron medullary collecting duct fossa substantia nigra Rostral migratory stream olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding microtubule binding GTP binding metal ion binding protein binding GTPase activity magnesium ion binding GTPase activating protein binding Cellular component cytoplasm centrosome Golgi apparatus cell projection membrane Golgi membrane spindle intracellular anatomical structure photoreceptor connecting cilium microtubule organizing center midbody spindle microtubule cytoplasmic microtubule extracellular exosome cytoskeleton nucleus cilium microtubule cytoskeleton Biological process cilium assembly kidney development intraciliary transport small GTPase mediated signal transduction photoreceptor cell development post-Golgi vesicle-mediated transport cell division protein transport cell cycle smoothened signaling pathway transport mitotic cytokinesis Golgi to plasma membrane transport protein localization to cilium protein localization to ciliary membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 403 56350 Ensembl ENSG00000138175 ENSMUSG00000025035 UniProt P36405 Q9WUL7 RefSeq (mRNA) NM_004311 NM_019718 NM_001355233 RefSeq (protein) NP_004302 NP_062692 NP_001342162 Location (UCSC) Chr 10: 102.67 – 102.71 Mb Chr 19: 46.52 – 46.56 Mb PubMed search [3] [4]
Wikidata
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Function

ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity.^[7]

Interactions

ARL3 has been shown to interact with Protein unc-119 homolog.^[8][9]