ARL4D

ADP-ribosylation factor-like protein 4D is a protein that in humans is encoded by the ARL4D gene.^[5][6]

ARL4D
Identifiers
Aliases	ARL4D, ARF4L, ARL6, ADP ribosylation factor like GTPase 4D
External IDs	OMIM: 600732; MGI: 1933155; HomoloGene: 1255; GeneCards: ARL4D; OMA:ARL4D - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 43,398,993 bp[1] End 43,401,137 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 101,556,367 bp[2] End 101,558,658 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx vena cava oocyte testicle parotid gland gingival epithelium right lobe of liver left lobe of thyroid gland nipple olfactory zone of nasal mucosa Top expressed in decidua gastrula neural layer of retina medial ganglionic eminence seminal vesicula left lobe of liver yolk sac retinal pigment epithelium myocardium of ventricle islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity Cellular component cytoplasm plasma membrane nucleolus intracellular anatomical structure membrane nucleus Biological process protein secretion intracellular protein transport vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 379 80981 Ensembl ENSG00000175906 ENSMUSG00000034936 UniProt P49703 Q99PE9 RefSeq (mRNA) NM_001661 NM_025404 RefSeq (protein) NP_001652 NP_079680 Location (UCSC) Chr 17: 43.4 – 43.4 Mb Chr 11: 101.56 – 101.56 Mb PubMed search [3] [4]
Wikidata
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Function

ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet–Biedl syndrome (BBS).^[6]