ARM390

ARM-390 is an opioid-analgesic compound selective for the delta opioid receptor.^[1][2][3]

AR-M 1000390

Clinical data
Other names	ARM-390
Identifiers
CAS Number	209808-01-5 209808-47-9 (HCl)
PubChem CID	9841259
IUPHAR/BPS	9005
ChemSpider	8016974
Chemical and physical data
Formula	C23H28N2O
Molar mass	348.490 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(CC)C(=O)C1=CC=C(C=C1)C(=C2CCNCC2)C3=CC=CC=C3
InChI InChI=1S/C23H28N2O/c1-3-25(4-2)23(26)21-12-10-19(11-13-21)22(18-8-6-5-7-9-18)20-14-16-24-17-15-20/h5-13,24H,3-4,14-17H2,1-2H3 Key:SMUGAZNLKPFBSB-UHFFFAOYSA-N

It is an exceptionally selective, potent δ opioid receptor agonist with an EC₅₀ of 7.2±0.9 nM for δ agonist potency.^[1]

In contrast to the delta-opioid selective agonist SNC-80, ARM390 was not found to produce receptor desensitization following multiple administrations. Although behavioral desensitization formed to the analgesic effect of ARM390 through a receptor internalization-independent mechanism, anxiolytic effects persisted during long-term treatment.^[4] ARM390 has been dubbed a "low-internalizing agonist" of delta opioid receptors.^[4]