ARMCX6

Armadillo repeat containing X-linked 6 is a protein that in humans is encoded by the ARMCX6 gene located on the X-chromosome.^[5]

ARMCX6
Identifiers
Aliases	ARMCX6, GASP10, armadillo repeat containing, X-linked 6, armadillo repeat containing X-linked 6
External IDs	MGI: 2147993; HomoloGene: 10373; GeneCards: ARMCX6; OMA:ARMCX6 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1 Start 101,615,118 bp[1] End 101,618,001 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X E3 Start 133,649,210 bp[2] End 133,652,166 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex body of pancreas left adrenal cortex smooth muscle tissue islet of Langerhans stromal cell of endometrium spleen monocyte right coronary artery lymph node Top expressed in ovary lens neural tube mesencephalon epiblast genital tubercle hypothalamus rhombencephalon neural layer of retina embryo More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 54470 278097 Ensembl ENSG00000198960 ENSMUSG00000050394 UniProt Q7L4S7 Q8K3A6 RefSeq (mRNA) NM_001009584 NM_001184768 NM_019007 NM_001007578 RefSeq (protein) NP_001009584 NP_001171697 NP_061880 NP_001007579 Location (UCSC) Chr X: 101.62 – 101.62 Mb Chr X: 133.65 – 133.65 Mb PubMed search [3] [4]
Wikidata
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It is one of six armadillo repeats containing X-linked proteins (ARMCX1, ARMCX2, ARMCX3, ARMCX4, ARMCX5, and ARMCX6 (this protein)).

The function of this protein is unknown at this time.

Protein sequence

     1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE 
    41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA 
    81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN 
   121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL 
   161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE 
   201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK 
   241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS 
   301 FMSLFIRNGN REILLETPAP

Homology

ARMCX6 is conserved in many eukaryotic organisms.

Orthologs

taxonomic name	common name	NCBI entry	Percentage of sequence similarity	Length (AAs)	comments
Homo sapiens	Human		100%	300	armadillo repeat containing X-linked 6
Macaca mulatta	Rhesus monkey		97.0%	300	PREDICTED: similar to amrmadillo repeat containing, X-linked 6 (H. sapiens)-like isoform 1
Equus caballus	Horse		90.0%	300	PREDICTED: similar to armadillo repeat containing, X-linked 6
Danio rerio	zebrafish		84.0%	301	Similar to RIKEN cDNA 0610039K22
Mus musculus	House Mouse		97.7%	393	armadillo repeat containing, X-linked 6 (H. sapiens)-like
Bos taurus	cow		83.0%	301	armadillo repeat containing, X-linked 6
Mus musculus	Mouse		82.0%	301	armadillo repeat containing, X-linked 6
Takifugu rubripes	Tetradontoidea		66.0%	818	aryl hydrocarbon receptor 2C
Caenorhabditis elegans	C. elegans		50.0%	332	Serpentine Receptor, class H family member (srh-216)
Saccharomyces cerevisiae	Yeast		70.0%	910	Hul5p
Gallus gallus	Chicken		52.0%	317	PREDICTED: hypothetical protein

Secondary Structure

The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below.^[6][7]

                          10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
ARMCX6      231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277
1DW9_A       19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65
                 + +   ++ +  +  + + +   +   + +    +  +  ++++

Cyanase segment having identity with ARMCX6.

Expression

Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice.^[8][9][10]